CXCR1+ neutrophil infiltration orchestrates response to third-generation EGFR-TKI in EGFR mutant non-small-cell lung cancer Genomic landscape of circulating tumor DNA in HER2-low metastatic breast cancer Anlotinib plus chemotherapy as a first-line treatment for gastrointestinal cancer patients with unresectable liver metastases: a multicohort, multicenter, exploratory trial Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2 First-line benmelstobart plus anlotinib and chemotherapy in advanced or metastatic/recurrent esophageal squamous cell carcinoma: a multi-center phase 2 study Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway Comparison of drug-eluting bead transarterial chemoembolization combined with apatinib versus drug-eluting bead transarterial chemoembolization for the treatment of unresectable hepatocellular carcinoma: a randomized, prospective, multicenter phase III trial 2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis Identifying genetic targets in clinical subtypes of Parkinson’s disease for optimizing pharmacological treatment strategies Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants

Targeted protein degradation: advances in drug discovery and clinical practice Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications

Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control Moving towards precision psychiatry: the hard nut of depression Multiplexed RNAs in lipid nanoparticles: potential therapeutic vaccine for chronic hepatitis B Intermittent high-fat diet: atherosclerosis progression by neutrophil reprogramming Mef2d: a novel transcription factor in type 2 allergic lung inflammation Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism Metformin: decelerates biomarkers of aging clocks Beyond the classic GPCR: unraveling the role of GPR155 role in cholesterol sensing and signaling Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates

A comprehensive proteomic analysis of umbilical cord blood supports COVID-19 vaccination before pregnancy